pentobarbital will lower the extent or influence of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Solid or average CYP3A4 inducers may increase amount of diazepam elimination; thus, efficacy of diazepam might be reduced.
pentobarbital will reduce the level or impact of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic effect of elbasvir/grazoprevir may be decreased if coadministered with robust CYP3A inducers and is particularly hence contraindicated.
Check Intently (1)pentobarbital will minimize the level or effect of benzhydrocodone/acetaminophen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Warning when discontinuing CYP3A4 inducers which have been coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone could boost and may result in possibly deadly respiratory despair.
pentobarbital will reduce the level or impact of losartan by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Mysterious.
pentobarbital will minimize the extent or influence of carbamazepine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Contraindicated (1)pentobarbital will reduce the level or impact of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Ladies mustn't pick out estradiol valerate/dienogest as their contraceptive although employing sturdy CYP3A4 inducers resulting from opportunity lessen in contraceptive efficacy.
Possibly boosts toxicity of the other by pharmacodynamic synergism. Steer clear of or Use Alternate Drug. Profound sedation, respiratory melancholy, coma, and Dying might final result if coadministered. Reserve concomitant prescribing of such drugs in patients for whom other therapy choices are insufficient. Limit dosages and durations to your least essential. Keep an eye on closely for signs of respiratory depression and sedation.
pentobarbital will lessen the level or influence of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lessen the level or influence of eltrombopag by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Check.
pentobarbital will decrease the extent or effect of mavacamten by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will lessen the level or effect of atazanavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
pentobarbital will lessen the level or impact of ambrisentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.
Training warning when administered to people with acute or Serious agony; could bring about paradoxical exhilaration or vital symptoms could be masked
pentobarbital will lessen the extent or impact check here of nitrendipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Not known.